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Another possibility leading to the decrease in glucose is a key enzymes activity decrease in the TCA, with both pyruvate dehydrogenase complex, which provides acetyl-CoA, and alpha-ketoglutarate dehydrogenase complex (KGDHC) decreasing in AD (Bubber et al., 2005)

Moreover, upon internalization of EV-derived VDAC1 protein by PTX-sensitive GC cells, these cells acquired a PTX-resistant phenotype manifested through AMPK activation and concomitant mTOR signaling pathway inactivation

DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimers disease

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